In biology, a Src homology domain is one of the two small protein binding domains found in the Src oncoprotein. Homologs of both the Src homology 2 and Src ...

Src homology domain containing inositol phosphatases (SHIPs), SHIP1 and SHIP2, are important members of this group. These proteins share 50% sequence identity ...

Src homology-2 (SH2) domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery.

The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal ...

Src homology (SH) domains are noncatalytic protein modules. SH2 domains bind to phosphotyrosine residues, whereas SH3 domains preferentially bind to proline ...

src Homology Domains. Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures.

Sep 27, 2010 · SH2 domains are thought to localize SHP2 to phosphorylated tyrosine residues on substrate proteins. Based on chromatography affinity and peptide ...

May 10, 2022 · The SRC homology (SH)3 family represents the archetypical modular protein interaction module, with ~300 annotated SH3 domains in humans that ...

Sep 14, 2012 · This report describes interactions between SH2 domains and potential binding partners that comprise initial signaling downstream of activated ...